Downloads

Data

 
Graubert TA, Cahan P, Edwin D, Selzer RR, Richmond TA, Eis PS, Shannon WD, Li X, McLeod HL, Cheverud JM, Ley TJ. A high-resolution map of segmental DNA copy number variation in the mouse genome. PLoS Genet. Epub 2006 Nov 22. PMID: 17206864 aCGH data
Cahan P, Godfrey LE, Eis PS, Richmond TA, Selzer RR, Brent M, McLeod HL, Ley TJ, Graubert TA. wuHMM: a robust algorithm to detect DNA copy number variation using long oligonucleotide microarray data. Nucleic Acids Res. Epub 2008 Mar 11. PMID:18334530 aCGH data
Cahan P, Li Y, Izumi M, Graubert TA. The impact of copy number variation on local gene expression in mouse hematopoietic stem/progenitor cells. Nature Genetics, In press. Array data
Supplementary Figure (17 Mb) Genome Browser

Tools/Software

wuHMM (Washington University Hidden Markov Model) is an algorithm for detecting DNA copy number variants (CNVs) from oligonucleotide array comparative genomic hybridization (aCGH) data. This package also contains an algorithm for assigning discrete CNV-region genotypes when multiple samples are available and data visualization tools. Code and documentation are available here.

 

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